as evaluated by Triton X treatment of sister cultures

These genetic results, are consistent with hormone receptors having vari ety of parallel but independent downstream results, and raise the question, Do post-operative AIS girls after 60 years have lower incidence of type-2 dibetes, because they are protected by being leaner and employing their energy in numerous way with more effi cient burn of their systemic disorder AUTONOMIC Fingolimod NERVOUS SYSTEM leptin hypothalamic sympathetic nervous system driven mechanism in health and LHS notion in AIS Trunk widening in normal adolescent girls and the putative LHS driven mechanism We postulate that in normal girls, trunk widening of the pelvis, ribcage and shoulder girdle, characteristic of humans, is contributed to by leptin hypothalamic sympthetic nervous system driven mechanism performing bilater friend. Differential sympathetic innervation between axial and appendicular bones could be present. The design of skeletal sizes for age implies that any differential innervation by Organism the sympathetic nerous process varies between girls and boys. In normal human growth, biacromial broadening reflects widening mainly of the underlying upper thorax, and pelvic broadening reflects iliac flaring and widening mainly of the sacral alae, the latter reaches its maximum in hominins to pro vide firm base of support for the trunk during bipedal posture and locomotion. Hominid lumbar vertebrae also show caudally progressive widening of their laminae and of the area separating their articular processes. Pelvic intake width is predictor of pediatric chest width. The evidence shows that pelvic widening inside the frontal plane, together with pelvic incidence in the sagittal plane, presented hominins with conservation of energy through UNC0638 biomechanical economy enabling bipedalism with upright posture, modified spinal movements, and within the last 3 million years growing fetal brain size with sagittal expansion irth canal, possibly with the bigger brain, from bigger baby,. longer lumbar region, and The evidence shows that the medio lateral dimension of the birth canal has been somewhat adequate since the australopithecine stage about 3 million years ago with funnel-shaped upper thorax, as in the contemporary chimpanzee. more ovoid pelvic form with increase particularly of the sagittal dimension, then developed in response to growing brain dimension particularly from about 0. 5 mya. The LHS concept for girls with AIS AIS in girls in the perspective of the autonomic nervous system is viewed as expressing improved main leptin sen sitivity of hypothalamic sympathetic functions and, in some girls, of the somatotropic axis, which subsequently develop an inverse relationship. We suppose that AIS arises from dysfunction of the normal LHS driven mechnism by genetically determined and selectively increased hypothalamic sensitivity to circulating leptin leading to hypothalamic asymmetry. The asymmetry is regarded as an adverse reaction to pressure, with asymmetric exercise medi ated vithe sympathetic nervous system bilaterally to ver tebrae and-or bones, to upper arm lengths in thoracic AIS, and to iliac levels in thoracolumbar and lumbar AIS. The increased sensitivity of the hypothalamus to leptin is viewed as being improved by increasing circu lating levels of leptin from the fat accumulation of adoles cent girls, despite the low leptin levels of AIS girls.